A Series of Discrete Repertoire Models Inspired by Lymphocyte Migration

White blood cells (lymphocytes) are critical to the recognition and response of the acquired immune system. These cells are mobile, migrating from primary lymphoid tissues, recirculating in the blood stream, trafficking though tissues of the body, and homing in to sites of infection and inflammation. Given an understanding of lymphocyte migration in the biological system, three areas of foundational model elements are proposed: (1) a series of architectural lymphatic tissue components, (2) a class system for lymphocyte differentiation based on their functional behaviour, and (3) a series of lymphocyte movement operators. These three major collections of foundational model elements are employed in the definition of a series of discretised repertoire adaptive models that rephrase and elaborate upon two existing discretised repertoire models. KeywordsAdaptive Models, Discrete Repertoire, Algorithms, Lymphocyte Migration, Trafficking, Homing, Recruitment,